We extend the definitions and main properties of graded extensions to the category of locally compact groupoids endowed with involutions. We introduce Real Čech cohomology, which is an equivariant-like cohomology theory suitable for the context of groupoids with involutions. The Picard group of such a groupoid is discussed and is given a cohomological picture. Eventually, we generalize Crainic's result, about the differential cohomology of a proper Lie groupoid with coefficients in a given representation, to the topological case.

Partially suported by the German Research Foundation (DFG) via the IRTG 1133.